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Tweetbot is an award-winning, native Twitter client for the Mac. This full-featured client has fantastic support for multiple accounts and lists. It also has powerful mute filters, multiple column views.
Designed for OS X: Tweetbot feels right at home in Yosemite with its beautiful interface, animations, support for Retina Displays and Notification Center.
Multiple Columns and Windows: Open saved searches, lists, mentions, direct message conversations and more into columns or windows and never miss a tweet.
Mute Filters: Hide tweets that you don