Top rated in Instant Messaging & VoIP
Send instant messages, share files, and hold video conferences.
iMessage lets you send messages to anyone on a Mac, or an iPhone, iPad...
Do more than just IM with Yahoo!
Popular and, probably, the best instant messaging client for you Mac.
One of the most advanced and feature rich video communication programs available to Mac users and allows people to connect with both Mac and PC users.
AIM keeps you connected to the people you care about right on your iPhone or iPod Touch.
VoIP program which allows you to make phone calls over the internet.
Send messages, make video calls and stay connected with your friends.
Send messages, exchange files, and make voice and video calls.
Powerful and efficient instant messaging client.
iGlasses allows you to adjust and manipulate your webcam's video settings.
QQ connects you to over 600 million Chinese QQ members and many of your favorite websites and useful tools.
Google, Skype, Yahoo, MSN, AIM, Jabber, Facebook, SMS, Fax...
Supports private and group communication as well as file exchanges.
Integrated functionality for instant messaging, presence, conferencing and voice.
Send messages, have group chats, and share pictures using the Whatsapp services.
Freeware Mac OS X IRC client created by Steve Green.
Spark is an open source, cross-platform instant messaging client for businesses.
Traditionally, chat clients on the Mac have been anything but glamorous.
Nimbuzz is everything you need to communicate for free.
Chat application that tries to integrate most of the major chat networks into one application.
Seek out friends and colleagues on the Internet with the latest version of this megapopular chat pro
With Livescribe Connect for smartpen, you can send notes and audio as pencast.
Nice Instant Messaging app for Facebook.