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BookReader is the Cocoa native application for reading electronic books in the following formats: fb2, ePUB, iBooks (including new epub3 with video, animations and interactive content), html, webarchive (Safari), doc (Microsoft Word), rtf, rtfd, txt
It is fully compatible with OS X Lion and Mountain Lion and has been successfully tested on new MacBookPro with Retina display.
BookReader now supports epub books with multimedia contents, es. html5 video, animations, interactive 3D contents, and all of that good stuff epub3 & html5 allows. As an example you can download epub with video from Download section.