Drawing with a tablet has always been a struggle. Typically, drawing programs (like most software) are designed to be used with a mouse. Tablet support is usually thrown in as an afterthought, under the theory that any pointing device will obey the same principles as a mouse. The result: an experience which only superficially captures the “feel” of a pen, while ignoring the subtle nuances.
Abandoning the traditional mouse-oriented paradigm, TabletDraw is designed from the ground up for use with a drawing tablet - specifically focusing on the realism of the drawing experience. Instead of setting brush thickness based solely on pen pressure, TabletDraw uses a combination of factors including speed and pen pressure to create a realistic pen-and-paper feel.
The bottom line: If you can draw on a piece of paper, you can draw with TabletDraw.