HueShifter is an amazing new application for doing color transposition or "color shifting" within images. Unlike other graphics applications, HueShifter works in perceptually uniform colorspaces (Lab and Luv) while letting you select and manipulate colors using dimensions that you're familiar with - hue, saturation and lightness. This allows you to make changes that are imperceptible and that look completely natural, changes that don't have halos and fringe effects around the affected colors.
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