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Wine & WineBottler builds for OS X - run windows applications on OS X.
WineBottler is a tool similar to codeweavers Crossover, where separate prefixes are created per app. However, WineBottler 'wraps' or 'bottles' the separate prefixes in an application bundle. WineBottler allows standalone (i.e. not requiring wine to be installed) applications to be created as well, by including the wine bundle inside the standalone application bundle.