iPodderX

iPodderX helps you subscribe to RSS newsfeeds with enclosures, also known as podcasts, and any files in those enclosures are automatically downloaded to your Mac.

Photos are shuffled off to iPhoto while music and audio is moved into iTunes where it can be synced with your iPod -- it's like Internet radio to go!
iPodderX is an advanced podcast client for the Mac and features an integrated Podcast Directory for easy finding of new and exciting podcasts, Keyword filtering so your feeds bring in only the files you're looking for, and much, much more. What's New
Version 2.2.8: Release notes were unavailable when this listing was updated. Requirements
PPC, Mac OS X 10.3.5 or later