GPSRouteX is a full-featured, auto-sequencing GPS route navigation application for Mac OS X... and it's only just begun!
GPSRouteX is designed to take full advantage of freely available data such as GPX files and Google Earth KML files. It is not moving-map GPS software, and it does not come with any data of its own. However, spend a while looking up freely available GPX data, and then pair it with Google Earth and gps2geX, and you'll have a full 3D "moving map" to complement the routing features of GPSRouteX (or use KisMAC to provide a more conventional 2D moving-map, and scan for wireless networks at the same time!). Turn-by-turn driving directions can be downloaded using Google Earth (save the directions as KML and import them into GPSRouteX)... or you can build your own custom routes quickly and easily (then export them to Google Earth so you can see your route on the "map").
Will not instal on my mid 2010 17" MB pro running OS X El Capitan. GPSDX says no software can be found. And GPSRouteX says "Check with the developer to make sure GPSRouteX works with this version of OS X. You may need to reinstall the application. Be sure to install any available updates for the application and OS X."